Exogenous Coronavirus Interacts With Endogenous Retrotransposon in Human Cells

There is an increased global outbreak of diseases caused by coronaviruses affecting respiratory tracts birds and mammals. Recent dangerous are MERS-CoV, SARS-CoV, SARS-CoV-2, causing illness even failure several organs. However, profound impact coronavirus on host cells remains elusive. In this study, we analyzed transcriptome SARS-CoV-2 infected human lung-derived cells, observed that infection these all induced increase retrotransposon expression with upregulation TET genes. Upregulation was also in intestinal organoids. Retrotransposon may lead to genome instability enhanced genes readthrough from retrotransposons. Therefore, people higher basal level such as cancer patients aged have risk symptomatic infection. Additionally, show evidence supporting long-term epigenetic inheritance upregulation. We chimeric transcripts RNA for potential invasion viral fragments, the front rear part being easier form RNA. Thus, suggest primers probes nucleic acid detection should be designed middle virus identify live probability. summary, propose our hypothesis invades interacts retrotransposon, eliciting more severe symptoms underlying diseases. treatment infection, it necessary pay attention harm contributed dysregulation.